Although chemotherapy is effective in combating cancer, its full benefits are often not realized because many patients do not take their medications as prescribed. There are many factors that contribute to poor medication adherence, including communication barriers, adverse events, and factors that are related to the therapy, such as prescription of complex drug regimens. Because barriers to medication adherence are complex and varied, solutions to improve adherence must also be multifactorial. Laura Wood, RN, MSN, OCN, Megan Price, MSN, APRN, FNP-C, and Virginia Seery, MSN, RN, ANP-BC, AOCNP, discuss their best practices to help patients adhere to their chemotherapy regimens.